水素分子が老化と難治性疾患に与える影響：ヒドロキシルラジカル消去の観点からの考察
Reactive oxygen species, particularly hydroxyl radicals (·OH), are identified as central contributors to cellular senescence and the progression of various diseases. Among candidate scavengers, molecular hydrogen (H₂) is highlighted as uniquely capable of penetrating mitochondrial membranes—the primary site of ·OH generation—and neutralizing these radicals. This review argues that endogenous and exogenous H₂ may contribute to both disease prevention and physiological recovery. A practical concern noted is the explosive nature of H₂ gas, which necessitates the engineering of safe inhalation devices suitable for domestic use. The authors advocate broader investigation into H₂ applications across aging-related and refractory conditions.
Molecular hydrogen penetrates mitochondrial membranes and selectively neutralizes hydroxyl radicals (·OH) generated predominantly within mitochondria, thereby reducing oxidative stress implicated in aging and disease pathogenesis.
For inhalation applications of molecular hydrogen, the lower flammability limit (LFL) deserves careful handling. The classical 4% figure applies to closed-system mixtures; the practical inhalation-environment threshold is 10%. Even pure-hydrogen output (the UFL 75% paradox) passes through the flammable range at the air–gas boundary. High-concentration (66% / 100%) inhalers are documented in the Japanese Consumer Affairs Agency accident-information database and are not recommended.
See also:
https://h2-papers.org/en/papers/32189669