漸増負荷運動中の換気・エルゴジェニック応答に対する分子状水素の抗酸化的影響：ヒトを対象としたランダム化クロスオーバー試験
This randomized, double-blind, crossover study enrolled 18 trained healthy participants who consumed hydrogen-rich calcium powder (HCP; 1500 mg/day, delivering 2.544 µg/day of H₂) or a matched placebo for three days before performing incremental cycling exercise. At rest, HCP was associated with reduced pulmonary ventilation and CO₂ output alongside elevated bicarbonate and PCO₂ levels. During exercise, pH declined significantly and bicarbonate remained elevated through the 240-watt workload in the HCP condition. Ventilation was lower with HCP, whereas CO₂ output and oxygen uptake were unaffected. Near-infrared spectroscopy revealed increased deoxygenation in the rectus femoris (RF) but not the vastus lateralis (VL), suggesting a disrupted oxygen delivery-to-utilization balance in the RF. These findings indicate that HCP-induced hypoventilation at rest may carry over into exercise, altering acid-base balance and regional muscle oxygenation in a muscle-specific manner potentially linked to differences in fiber-type composition and vascular control.
HCP supplementation appears to enhance resting antioxidant capacity, leading to hypoventilation that reduces pH and sustains elevated bicarbonate during exercise; this may impair the oxygen delivery-to-utilization ratio specifically in the rectus femoris, possibly due to its distinct fiber-type and vascular regulatory properties.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/33573133