不安定狭心症に対する水素補助投与の効果：in vitro および臨床試験による検討
Oxidative stress and inflammation are central to the pathophysiology of atherosclerotic cardiovascular disease. Using an ox-LDL-induced injury model in human umbilical vein endothelial cells, this study demonstrated that hydrogen suppresses oxidative stress and inflammatory responses through downregulation of the LOX-1/NF-κB signaling pathway. A subsequent clinical component enrolled 40 hospitalized patients with unstable angina, who received either 1000–1200 mL/day of hydrogen-rich water or an equivalent volume of placebo water alongside standard pharmacotherapy for three months. Patients in the hydrogen-rich water group showed alleviation of angina symptoms. Serum lipid analysis revealed greater reductions in total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B concentrations compared with conventional pharmacotherapy alone. These findings indicate that hydrogen-rich water supplementation may confer additional cardiovascular benefit in unstable angina.
Hydrogen downregulates the LOX-1/NF-κB signaling pathway, thereby suppressing ox-LDL-induced oxidative stress and inflammatory responses in endothelial cells.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/33899541