COVID-19における内因性水素ガス産生異常の可能性
COVID-19 is associated with extensive alterations in gut microbiota composition, including a reduction in hydrogen-producing bacterial species, which may lead to decreased endogenous dihydrogen (H2) output. As a biologically active gaseous molecule, H2 exerts cytoprotective, antioxidant, anti-inflammatory, and antiapoptotic effects. This review proposes that diminished H2 production could contribute to disease progression and severity in COVID-19. Exogenous H2 supplementation is discussed as a potential approach to restore physiological H2 levels, with the possibility of combining H2 measurement and supplementation as a combined diagnostic and interventional strategy. The paper also situates H2 alongside other gasotransmitters such as nitric oxide and hydrogen sulfide in the context of COVID-19-related gaseous signaling disruption.
COVID-19-induced gut dysbiosis reduces the abundance of H2-producing bacteria, lowering endogenous dihydrogen levels. Because H2 normally exerts antioxidant, anti-inflammatory, and antiapoptotic effects, its deficiency may impair host defense mechanisms and contribute to disease worsening.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/35967841