分子状水素の医療応用に関する研究動向：書誌計量学的分析
A bibliometric study examined 1,126 PubMed-indexed publications on the medical use of molecular hydrogen published through July 2021. Annual publication counts showed a consistent upward trajectory from 2007 to 2020. Keyword co-occurrence analysis identified oxidative stress, inflammation, hydrogen-rich water, and hydrogen gas as the most frequently appearing terms. More recently emerging keywords included gut microbiota, pyroptosis, and COVID-19, suggesting these as potential future research hotspots. The analysis provides a structured overview of how the field has evolved and where investigative interest is likely to concentrate in coming years.
Oxidative stress and inflammation represent the dominant mechanistic themes in the literature; gut microbiota modulation and pyroptosis are identified as emerging mechanistic areas of interest.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/37077121