コエンザイムQ10がラット腸内細菌叢の組成および水素・メタン・短鎖脂肪酸・トリメチルアミン産生に与える影響
This rat study examined how oral coenzyme Q10 (CoQ10) at 30 mg/kg/day for 21 days affects gut microbiota-derived biomarkers. Because CoQ10 bioavailability is only 2–3%, substantial amounts accumulate in the intestinal lumen and may influence microbial communities. Measurements taken before and after the administration period included breath hydrogen and methane (lactulose breath test), fecal and blood short-chain fatty acids (SCFA) and fecal trimethylamine (TMA) by NMR, and microbiome composition by 16S rRNA sequencing. Results showed a 1.83-fold rise in total hydrogen concentration, a 63% increase in total fecal SCFA, a 126% increase in butyrate specifically, and a 6.56-fold reduction in TMA. Relative abundances of certain bacterial taxa shifted significantly. These findings suggest that CoQ10-driven remodeling of gut microbiota composition leads to elevated molecular hydrogen generation, which may contribute to the compound's antioxidant properties, while increased butyrate production may support intestinal barrier integrity.
Oral CoQ10 appears to remodel gut microbiota taxonomic composition, thereby increasing microbial production of molecular hydrogen (an antioxidant) and butyrate (a gut barrier protectant), while reducing trimethylamine levels.
This study is at the animal-experiment stage. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/37242469