固体原子水素による広域RONS消去と糖尿病性創傷治癒促進
Tungsten bronze phase HWO (HWO) was identified as a solid-state hydrogen carrier capable of releasing atomic hydrogen in a temperature-dependent manner, exhibiting broad-spectrum scavenging of reactive oxygen and nitrogen species (RONS) distinct from molecular hydrogen. The material also displays pH-responsive biodegradability, enabling clearance from pathological sites after use. In a diabetic wound animal model, HWO administration promoted M2-type macrophage polarization and anti-inflammatory cytokine production, which in turn stimulated vascular formation and accelerated chronic wound closure. These findings broaden the known categories of hydrogen-based therapeutic materials and support investigation of diverse physical forms of hydrogen as RONS scavengers.
Atomic hydrogen released from HWO scavenges a broad spectrum of RONS, promotes M2-type macrophage polarization and anti-inflammatory cytokine production, and thereby stimulates angiogenesis to accelerate diabetic wound closure.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
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https://h2-papers.org/en/papers/38213516