マグネシウム埋植による持続的水素産生が心筋梗塞ラットモデルに与える影響
Molecular hydrogen has attracted attention as a broad-spectrum antioxidant with potential applications in myocardial infarction (MI); however, inhalation-based delivery achieves only low concentrations in target organs with a limited duration of action. This study investigated subcutaneous implantation of magnesium slices in the dorsal region of rats as a means of generating hydrogen continuously through reactions with the body's internal environment. Hydrogen output, production efficiency, and safety were systematically assessed. Compared with inhalation, the implantation approach produced higher hydrogen concentrations over a longer period and led to significant improvements in cardiac function in MI rats. Additionally, free radicals arising from mitochondrial dysfunction were scavenged, and cardiomyocyte apoptosis was suppressed. These findings suggest that magnesium-based implantable hydrogen generation may overcome key limitations of conventional delivery routes for cardiac applications.
Subcutaneously implanted magnesium reacts with the physiological environment to generate hydrogen continuously, enabling sustained free-radical scavenging of mitochondria-derived reactive oxygen species and suppression of cardiomyocyte apoptosis, thereby improving cardiac function.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/38745034