術後癒着予防における水素の可能性：抗炎症・抗酸化・抗線維化メカニズムに関するレビュー
This review examined the available literature from PubMed and Google Scholar to evaluate the role of molecular hydrogen in preventing post-surgical adhesions and the underlying biological mechanisms. Molecular hydrogen possesses selective antioxidant, anti-inflammatory, and anti-fibrotic properties with potential applications in conditions such as acute pancreatitis, respiratory disorders, and ischemia-reperfusion injury. Post-surgical adhesions, which contribute to chronic pain, organ dysfunction, and acute complications, are fundamentally driven by inflammation, oxidative stress, and fibrosis. Surgical trauma triggers immune cell recruitment and elevated pro-inflammatory cytokine levels, promoting adhesion formation. Evidence indicates that hydrogen can suppress early inflammatory responses by downregulating pro-inflammatory cytokines while simultaneously exerting antioxidant and anti-fibrotic effects. The authors conclude that further investigation into the precise molecular pathways and additional clinical studies are warranted to fully characterize hydrogen's efficacy and safety profile in this context.
Molecular hydrogen suppresses early post-surgical inflammatory responses by downregulating pro-inflammatory cytokines, while its antioxidant activity reduces oxidative stress and its anti-fibrotic properties inhibit fibrosis, collectively limiting adhesion formation.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/40017254