H₂
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antioxidant enzymes
423 papers
Delivery-method distribution
hydrogen-rich water: 179
in vitro: 65
inhalation: 48
mixed routes: 47
injection / infusion: 36
not specified: 30
animal model: 8
topical application: 7
hydrogen bath: 3
Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses.
2013 ・ J Equine Sci ・ PMID 24833996
hydrogen-rich water
positive
animal study
Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH).
2013 ・ Int J Mol Sci ・ PMID 24132155
hydrogen-rich water
not assessed
review
Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.
2013 ・ Clin Transl Sci ・ PMID 24127924
hydrogen-rich water
mixed
human randomized controlled trial
Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression.
2013 ・ Free Radic Biol Med ・ PMID 23954468
hydrogen-rich water
positive
animal study
Molecular hydrogen is involved in phytohormone signaling and stress responses in plants.
2013 ・ PLoS One ・ PMID 23951075
hydrogen-rich water
positive
other
Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water.
2013 ・ J Hazard Mater ・ PMID 23846121
hydrogen-rich water
positive
in vitro study
Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.
2013 ・ Med Gas Res ・ PMID 23816239
injection / infusion
positive
human case report
Protective effects of hydrogen-rich saline on ulcerative colitis rat model.
2013 ・ J Surg Res ・ PMID 23773716
injection / infusion
positive
animal study
The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance.
2013 ・ Med Gas Res ・ PMID 23680032
mixed routes
not assessed
review
Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.
2013 ・ Mov Disord ・ PMID 23400965
hydrogen-rich water
positive
human randomized controlled trial
Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.
2013 ・ Mol Cell Biochem ・ PMID 23212446
in vitro
positive
in vitro study
Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis.
2012 ・ Shock ・ PMID 23160520
inhalation
positive
animal study
Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines.
2012 ・ Brain Res ・ PMID 23010312
injection / infusion
positive
animal study
Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress.
2012 ・ Chin Med J (Engl) ・ PMID 22800834
injection / infusion
positive
animal study
Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats.
2012 ・ J Neurosci Res ・ PMID 22589232
injection / infusion
positive
animal study
Molecular hydrogen and radiation protection.
2012 ・ Free Radic Res ・ PMID 22537465
mixed routes
positive
review
Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
2012 ・ Med Gas Res ・ PMID 22520831
hydrogen-rich water
positive
human randomized controlled trial
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
2012 ・ J Surg Res ・ PMID 22475349
injection / infusion
positive
animal study
Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
2012 ・ Med Sci Monit ・ PMID 22367121
injection / infusion
positive
animal study
Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.
2012 ・ Cardiovasc Res ・ PMID 22287575
hydrogen-rich water
positive
animal study
Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.
2012 ・ Exp Eye Res ・ PMID 22154552
injection / infusion
positive
animal study
Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway.
2012 ・ Atherosclerosis ・ PMID 22153150
injection / infusion
positive
animal study
Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.
2012 ・ Biochim Biophys Acta ・ PMID 21621588
mixed routes
not assessed
review
Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model.
2011 ・ Med Gas Res ・ PMID 22146083
hydrogen-rich water
positive
animal study
Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.
2011 ・ Med Gas Res ・ PMID 22146004
hydrogen-rich water
positive
human randomized controlled trial
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