H₂
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diabetes / metabolic syndrome
49 papers
Delivery-method distribution
hydrogen-rich water: 26
mixed routes: 7
not specified: 5
topical application: 4
injection / infusion: 3
inhalation: 2
in vitro: 1
animal model: 1
The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats.
2022 ・ Vet World ・ PMID 35369585
hydrogen-rich water
positive
animal study
Symbiotic Algae-Bacteria Dressing for Producing Hydrogen to Accelerate Diabetic Wound Healing.
2022 ・ Nano Lett ・ PMID 34928162
topical application
positive
in vitro study
Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.
2021 ・ Korean J Physiol Pharmacol ・ PMID 34697262
hydrogen-rich water
positive
animal study
The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus.
2021 ・ Mol Cell Biochem ・ PMID 33830396
hydrogen-rich water
positive
animal study
Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.
2020 ・ Med Gas Res ・ PMID 33004708
hydrogen-rich water
positive
human observational study
Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress.
2020 ・ Exp Ther Med ・ PMID 32537002
animal model
positive
animal study
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial.
2020 ・ Diabetes Metab Syndr Obes ・ PMID 32273740
hydrogen-rich water
positive
human randomized controlled trial
Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.
2020 ・ Mol Med Rep ・ PMID 31746358
injection / infusion
positive
animal study
L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet.
2019 ・ Nutrients ・ PMID 31847305
hydrogen-rich water
positive
animal study
Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.
2018 ・ Ir J Med Sci ・ PMID 28560519
hydrogen-rich water
mixed
human randomized controlled trial
Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ.
2017 ・ Mol Med Rep ・ PMID 28098910
injection / infusion
positive
animal study
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.
2016 ・ NPJ Aging Mech Dis ・ PMID 28721265
hydrogen-rich water
positive
animal study
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.
2015 ・ Cardiovasc Pathol ・ PMID 25979689
hydrogen-rich water
positive
animal study
Molecular hydrogen: An inert gas turns clinically effective.
2015 ・ Ann Med ・ PMID 25936365
mixed routes
not assessed
review
Induced fit docking, pharmacophore modeling, and molecular dynamic simulations on thiazolidinedione derivatives to explore key interactions with Tyr48 in polyol pathway.
2014 ・ J Mol Model ・ PMID 24974084
in vitro
positive
in vitro study
Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.
2013 ・ Mol Neurobiol ・ PMID 23436141
not specified
not assessed
review
Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress.
2012 ・ Chin Med J (Engl) ・ PMID 22800834
injection / infusion
positive
animal study
Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney.
2012 ・ Med Gas Res ・ PMID 22776773
hydrogen-rich water
positive
animal study
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.
2012 ・ Oxid Med Cell Longev ・ PMID 22720117
mixed routes
not assessed
review
Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model.
2011 ・ Med Gas Res ・ PMID 22146083
hydrogen-rich water
positive
animal study
The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.
2011 ・ Curr Pharm Des ・ PMID 21736540
not specified
not assessed
review
Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.
2011 ・ Obesity (Silver Spring) ・ PMID 21293445
hydrogen-rich water
positive
animal study
Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study.
2010 ・ J Clin Biochem Nutr ・ PMID 20216947
hydrogen-rich water
positive
human observational study
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
2008 ・ Nutr Res ・ PMID 19083400
hydrogen-rich water
positive
human randomized controlled trial
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