H₂
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hydroxyl radical scavenging
352 papers
Delivery-method distribution
hydrogen-rich water: 93
mixed routes: 71
inhalation: 66
in vitro: 41
injection / infusion: 34
not specified: 31
topical application: 9
animal model: 7
Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.
2012 ・ Med Gas Res ・ PMID 23031079
hydrogen-rich water
positive
human observational study
Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice.
2012 ・ PLoS One ・ PMID 22860058
hydrogen-rich water
positive
animal study
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.
2012 ・ Oxid Med Cell Longev ・ PMID 22720117
mixed routes
not assessed
review
Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers.
2012 ・ Med Gas Res ・ PMID 22607973
mixed routes
positive
human case report
Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats.
2012 ・ J Neurosci Res ・ PMID 22589232
injection / infusion
positive
animal study
Molecular hydrogen and radiation protection.
2012 ・ Free Radic Res ・ PMID 22537465
mixed routes
positive
review
Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice.
2012 ・ Hepatology ・ PMID 22505328
hydrogen-rich water
positive
animal study
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
2012 ・ J Surg Res ・ PMID 22475349
injection / infusion
positive
animal study
Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.
2012 ・ Med Sci Monit ・ PMID 22460088
injection / infusion
positive
animal study
Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
2012 ・ Med Sci Monit ・ PMID 22367121
injection / infusion
positive
animal study
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.
2012 ・ Crit Care Med ・ PMID 22336722
inhalation
positive
animal study
Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.
2012 ・ Exp Eye Res ・ PMID 22154552
injection / infusion
positive
animal study
Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.
2012 ・ Biochim Biophys Acta ・ PMID 21621588
mixed routes
not assessed
review
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.
2011 ・ Med Gas Res ・ PMID 22146674
hydrogen-rich water
mixed
human randomized controlled trial
Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide.
2011 ・ Med Gas Res ・ PMID 22146365
in vitro
positive
in vitro study
Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model.
2011 ・ Med Gas Res ・ PMID 22146083
hydrogen-rich water
positive
animal study
Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.
2011 ・ Med Gas Res ・ PMID 22146004
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen-rich water attenuates experimental periodontitis in a rat model.
2011 ・ J Clin Periodontol ・ PMID 22092571
hydrogen-rich water
positive
animal study
Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle.
2011 ・ J Physiol Anthropol ・ PMID 21963827
hydrogen-rich water
mixed
animal study
Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging.
2011 ・ Jpn J Radiol ・ PMID 21882093
hydrogen-rich water
positive
animal study
Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress.
2011 ・ Am J Physiol Lung Cell Mol Physiol ・ PMID 21764987
mixed routes
positive
animal study
Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water--participation of Pt nanoparticles.
2011 ・ Biosci Biotechnol Biochem ・ PMID 21737933
hydrogen-rich water
mixed
animal study
Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.
2011 ・ Curr Pharm Des ・ PMID 21736547
mixed routes
not assessed
review
The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.
2011 ・ Curr Pharm Des ・ PMID 21736540
not specified
not assessed
review
Protective effect of hydrogen-rich saline on decompression sickness in rats.
2011 ・ Aviat Space Environ Med ・ PMID 21702310
injection / infusion
positive
animal study
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