H₂
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hydroxyl radical scavenging
352 papers
Delivery-method distribution
hydrogen-rich water: 93
mixed routes: 71
inhalation: 66
in vitro: 41
injection / infusion: 34
not specified: 31
topical application: 9
animal model: 7
Therapeutic effects of hydrogen in animal models of Parkinson's disease.
2011 ・ Parkinsons Dis ・ PMID 21687749
not specified
not assessed
review
A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.
2011 ・ Med Sci Monit ・ PMID 21455114
inhalation
not assessed
letter
Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats.
2011 ・ J Biomed Biotechnol ・ PMID 21318114
hydrogen-rich water
positive
animal study
EELS characterization of radiolytic products in frozen samples.
2011 ・ Micron ・ PMID 21111626
in vitro
not assessed
in vitro study
Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs.
2011 ・ Neurosci Lett ・ PMID 20888392
hydrogen-rich water
positive
animal study
Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.
2011 ・ Med Hypotheses ・ PMID 20851533
mixed routes
not assessed
other
The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.
2010 ・ West Indian Med J ・ PMID 21275114
injection / infusion
not assessed
letter
The potential cardioprotective effects of hydrogen in irradiated mice.
2010 ・ J Radiat Res ・ PMID 21116102
hydrogen-rich water
positive
animal study
Saturated hydrogen saline protects the lung against oxygen toxicity.
2010 ・ Undersea Hyperb Med ・ PMID 20568549
injection / infusion
positive
animal study
Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT.
2010 ・ Br J Radiol ・ PMID 20505032
hydrogen-rich water
positive
animal study
Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model.
2010 ・ Shock ・ PMID 20351628
inhalation
positive
animal study
Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study.
2010 ・ J Clin Biochem Nutr ・ PMID 20216947
hydrogen-rich water
positive
human observational study
Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats.
2010 ・ Biochem Biophys Res Commun ・ PMID 20138831
injection / infusion
positive
animal study
Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
2010 ・ Shock ・ PMID 19997046
inhalation
positive
animal study
Oral hydrogen water prevents chronic allograft nephropathy in rats.
2010 ・ Kidney Int ・ PMID 19907413
hydrogen-rich water
positive
animal study
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury.
2010 ・ Invest Ophthalmol Vis Sci ・ PMID 19834032
topical application
positive
animal study
Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
2009 ・ PLoS One ・ PMID 19789628
hydrogen-rich water
positive
animal study
Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats.
2009 ・ Exp Biol Med (Maywood) ・ PMID 19596825
injection / infusion
positive
animal study
Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.
2009 ・ Biochem Biophys Res Commun ・ PMID 19486890
hydrogen-rich water
positive
animal study
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.
2009 ・ Neurosci Lett ・ PMID 19356598
hydrogen-rich water
positive
animal study
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.
2009 ・ Cancer Chemother Pharmacol ・ PMID 19148645
mixed routes
positive
animal study
Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.
2009 ・ Neuropsychopharmacology ・ PMID 18563058
hydrogen-rich water
positive
animal study
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
2008 ・ Nutr Res ・ PMID 19083400
hydrogen-rich water
positive
human randomized controlled trial
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.
2007 ・ Biochem Biophys Res Commun ・ PMID 17673169
inhalation
positive
animal study
Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
2001 ・ C R Acad Sci III ・ PMID 11510417
inhalation
positive
animal study
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