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liver disease
56 papers
Delivery-method distribution
hydrogen-rich water: 32
inhalation: 5
in vitro: 5
mixed routes: 4
injection / infusion: 4
animal model: 4
not specified: 2
Silicon-based agent mitigates fatty liver formation in a CDAHFD60-induced MASH mouse model by enhancing hepatic function.
2026 ・ Biochem Biophys Rep ・ PMID 41890216
hydrogen-rich water
positive
animal study
Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury.
2026 ・ Antioxidants (Basel) ・ PMID 41750640
hydrogen-rich water
positive
animal study
Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.
2026 ・ J Nutr Biochem ・ PMID 41207540
hydrogen-rich water
positive
animal study
Molecular mechanisms associated with effects of hydrogen molecule in liver diseases: the review of current evidence.
2025 ・ Eur J Med Res ・ PMID 41194243
mixed routes
not assessed
review
Silicon Nanostructures for Hydrogen Generation and Storage.
2025 ・ Nanomaterials (Basel) ・ PMID 41090875
not specified
not assessed
review
Treatment with hydrogen-rich water protects against thioacetamide-induced hepatic encephalopathy in rats through stabilizing liver-brain disturbance.
2025 ・ Sci Rep ・ PMID 40410340
hydrogen-rich water
positive
animal study
Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization.
2025 ・ In Vivo ・ PMID 40295001
hydrogen-rich water
positive
human case report
Long-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice.
2025 ・ PLoS One ・ PMID 39951412
hydrogen-rich water
positive
animal study
The impact of hydrogen-rich water on liver enzyme levels in clinical populations: a comprehensive review and meta-analysis.
2024 ・ Gastroenterol Hepatol Bed Bench ・ PMID 40406427
hydrogen-rich water
positive
meta-analysis
Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells.
2024 ・ Biomedicines ・ PMID 39062020
in vitro
positive
in vitro study
A Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease.
2024 ・ Antioxidants (Basel) ・ PMID 38929185
animal model
positive
animal study
Hydrogen-rich water supplementation improves metabolic profile during peripartum period in Gurcu goats and enhances the health and survival of kids.
2024 ・ Res Vet Sci ・ PMID 38458045
hydrogen-rich water
mixed
animal study
The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme QLevels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.
2023 ・ Int J Mol Sci ・ PMID 37569850
hydrogen-rich water
positive
human randomized controlled trial
Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment.
2023 ・ Pharmaceuticals (Basel) ・ PMID 37375765
not specified
not assessed
review
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
2023 ・ Theranostics ・ PMID 37215568
mixed routes
positive
animal study
Novel therapeutic approaches based on the pathological role of gut dysbiosis on the link between nonalcoholic fatty liver disease and insulin resistance.
2023 ・ Eur Rev Med Pharmacol Sci ・ PMID 36930488
hydrogen-rich water
not assessed
review
[Alleviating effects of hydrogen on hyperhomocysteinemia and fatty liver induced by high-methionine diet].
2022 ・ Zhongguo Ying Yong Sheng Li Xue Za Zhi ・ PMID 37308436
hydrogen-rich water
positive
animal study
Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial.
2022 ・ Antioxidants (Basel) ・ PMID 36290657
hydrogen-rich water
mixed
human randomized controlled trial
A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease.
2022 ・ J Cell Mol Med ・ PMID 35734974
mixed routes
positive
human randomized controlled trial
Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways.
2022 ・ Sci Rep ・ PMID 35273249
mixed routes
positive
animal study
Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs.
2021 ・ Heliyon ・ PMID 34816046
hydrogen-rich water
not assessed
animal study
Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.
2021 ・ Trials ・ PMID 34674744
inhalation
not assessed
human randomized controlled trial
The Preventive Role of Hydrogen-Rich Water in Thioacetamide-Induced Cholangiofibrosis in Rat Assessed by Automated Histological Classification.
2021 ・ Front Pharmacol ・ PMID 34489690
hydrogen-rich water
positive
animal study
Electrolyzed Hydrogen Water Protects against Ethanol-Induced Cytotoxicity by Regulating Aldehyde Metabolism-Associated Enzymes in the Hepatic Cell Line HepG2.
2021 ・ Antioxidants (Basel) ・ PMID 34069398
in vitro
positive
in vitro study
The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus.
2021 ・ Mol Cell Biochem ・ PMID 33830396
hydrogen-rich water
positive
animal study
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