水素リッチ溶液摂取後の水素薬物動態：ブタを用いた検討
Oral consumption of hydrogen-rich water is widely practiced, yet the associated pharmacokinetics had not been characterized. In this study, four 8-week-old female pigs received 500 ml of either hydrogen-rich or hydrogen-free glucose solution infused into the jejunum within 2 minutes via percutaneous gastrostomy. Hydrogen concentrations were monitored over 120 minutes in the portal vein, suprahepatic inferior vena cava, and carotid artery. Following hydrogen-rich solution administration, portal vein hydrogen peaked at 0.05 mg/L and remained above 0.016 mg/L (approximately 1% saturation) at 60 minutes. In contrast, carotid arterial hydrogen was undetectable, suggesting hepatic metabolism or pulmonary elimination before systemic circulation. The findings indicate that rapid ingestion of a highly concentrated hydrogen solution effectively elevates portal blood hydrogen levels and delivers hydrogen to the liver.
Hydrogen absorbed from the jejunum elevates portal vein concentrations, but systemic arterial delivery appears limited due to hepatic metabolism or pulmonary elimination, preventing significant passage into the carotid circulation.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/34816046