H₂
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oxidative stress
899 papers
Delivery-method distribution
hydrogen-rich water: 313
inhalation: 153
mixed routes: 150
in vitro: 103
injection / infusion: 72
not specified: 66
topical application: 19
animal model: 15
hydrogen bath: 8
Induced fit docking, pharmacophore modeling, and molecular dynamic simulations on thiazolidinedione derivatives to explore key interactions with Tyr48 in polyol pathway.
2014 ・ J Mol Model ・ PMID 24974084
in vitro
positive
in vitro study
Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats.
2014 ・ Toxicol Appl Pharmacol ・ PMID 24967689
hydrogen-rich water
positive
animal study
Molecular hydrogen attenuates neuropathic pain in mice.
2014 ・ PLoS One ・ PMID 24941001
hydrogen-rich water
positive
animal study
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
2014 ・ Int Immunopharmacol ・ PMID 24929023
injection / infusion
positive
human randomized controlled trial
Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush.
2014 ・ PLoS One ・ PMID 24915536
injection / infusion
positive
animal study
Hydrogen gas presents a promising therapeutic strategy for sepsis.
2014 ・ Biomed Res Int ・ PMID 24829918
inhalation
not assessed
review
Hydrogen-rich water confers plant tolerance to mercury toxicity in alfalfa seedlings.
2014 ・ Ecotoxicol Environ Saf ・ PMID 24793520
hydrogen-rich water
positive
in vitro study
Effect of hydrogen-rich water on acute peritonitis of rat models.
2014 ・ Int Immunopharmacol ・ PMID 24793096
hydrogen-rich water
positive
animal study
Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.
2014 ・ Pharmacol Ther ・ PMID 24769081
mixed routes
not assessed
review
Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats.
2014 ・ CNS Neurosci Ther ・ PMID 24685114
injection / infusion
positive
animal study
Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats.
2014 ・ Mol Cell Biochem ・ PMID 24652103
hydrogen-rich water
positive
animal study
Hydrogen-rich water delays postharvest ripening and senescence of kiwifruit.
2014 ・ Food Chem ・ PMID 24629944
hydrogen-rich water
positive
other
Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water.
2014 ・ BMC Complement Altern Med ・ PMID 24589018
hydrogen-rich water
positive
animal study
Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.
2014 ・ World J Gastroenterol ・ PMID 24587639
hydrogen-rich water
positive
animal study
Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress.
2014 ・ Med Hypotheses ・ PMID 24529916
not specified
not assessed
other
Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.
2014 ・ Free Radic Biol Med ・ PMID 24509162
hydrogen-rich water
positive
animal study
Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death.
2014 ・ Chem Biol Interact ・ PMID 24491676
in vitro
positive
in vitro study
Medical applications of breath hydrogen measurements.
2014 ・ Anal Bioanal Chem ・ PMID 24481621
not specified
not assessed
review
Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production.
2014 ・ J Hazard Mater ・ PMID 24413050
hydrogen-rich water
positive
in vitro study
Hydrogen-rich water affected blood alkalinity in physically active men.
2014 ・ Res Sports Med ・ PMID 24392771
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner.
2014 ・ J Plant Physiol ・ PMID 24331413
in vitro
positive
in vitro study
Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.
2014 ・ Hemodial Int ・ PMID 24274030
injection / infusion
positive
human randomized controlled trial
Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells.
2014 ・ J Bone Miner Metab ・ PMID 24196871
in vitro
positive
in vitro study
Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses.
2013 ・ J Equine Sci ・ PMID 24833996
hydrogen-rich water
positive
animal study
Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.
2013 ・ Sci Rep ・ PMID 24253616
hydrogen-rich water
positive
animal study
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