H₂
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reactive oxygen species
774 papers
Delivery-method distribution
hydrogen-rich water: 224
in vitro: 135
inhalation: 133
mixed routes: 118
not specified: 75
injection / infusion: 58
topical application: 14
animal model: 12
hydrogen bath: 5
COVID-19 and molecular hydrogen inhalation.
2020 ・ Ther Adv Respir Dis ・ PMID 32865158
inhalation
not assessed
letter
Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application.
2020 ・ Curr Opin Anaesthesiol ・ PMID 32826628
mixed routes
not assessed
review
Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury.
2020 ・ Brain Res ・ PMID 32814064
inhalation
positive
animal study
Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model.
2020 ・ Shock ・ PMID 32804466
inhalation
positive
animal study
Molecular hydrogen: A potential radioprotective agent.
2020 ・ Biomed Pharmacother ・ PMID 32763820
mixed routes
not assessed
review
Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
2020 ・ Sci Rep ・ PMID 32704088
inhalation
positive
animal study
Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial.
2020 ・ Sci Rep ・ PMID 32699287
hydrogen-rich water
mixed
human randomized controlled trial
An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress.
2020 ・ Oxid Med Cell Longev ・ PMID 32655773
topical application
positive
animal study
Pharmacokinetics of a single inhalation of hydrogen gas in pigs.
2020 ・ PLoS One ・ PMID 32559239
inhalation
not assessed
animal study
Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress.
2020 ・ Exp Ther Med ・ PMID 32537002
animal model
positive
animal study
Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial.
2020 ・ PLoS One ・ PMID 32470022
hydrogen-rich water
positive
human randomized controlled trial
A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats.
2020 ・ Int J Oral Maxillofac Surg ・ PMID 32451233
mixed routes
positive
animal study
Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32447221
inhalation
positive
animal study
Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.
2020 ・ F1000Res ・ PMID 32399209
hydrogen bath
positive
human case report
Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.
2020 ・ PLoS One ・ PMID 32302306
inhalation
positive
animal study
The role and proteomic analysis of ethylene in hydrogen gas-induced adventitious rooting development in cucumber (L.) explants.
2020 ・ PeerJ ・ PMID 32292654
hydrogen-rich water
positive
in vitro study
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial.
2020 ・ Diabetes Metab Syndr Obes ・ PMID 32273740
hydrogen-rich water
positive
human randomized controlled trial
Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method.
2020 ・ Front Med (Lausanne) ・ PMID 32266279
hydrogen-rich water
positive
animal study
Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling.
2020 ・ J Invest Dermatol ・ PMID 32234461
in vitro
positive
in vitro study
A "philosophical molecule," hydrogen may overcome senescence and intractable diseases.
2020 ・ Med Gas Res ・ PMID 32189669
inhalation
not assessed
review
Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males.
2020 ・ Med Gas Res ・ PMID 32189665
hydrogen-rich water
positive
human randomized controlled trial
Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32058932
inhalation
positive
animal study
Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.
2020 ・ J Biochem Mol Toxicol ・ PMID 32040235
hydrogen-rich water
positive
animal study
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
2020 ・ Sci Rep ・ PMID 32029879
mixed routes
positive
human observational study
Transcriptome analysis reveals insight into molecular hydrogen-induced cadmium tolerance in alfalfa: the prominent role of sulfur and (homo)glutathione metabolism.
2020 ・ BMC Plant Biol ・ PMID 32019510
hydrogen-rich water
positive
in vitro study
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