stroke / cerebral ischemia

31 papers

• Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.
  2026 ・ J Stroke Cerebrovasc Dis ・ PMID 42049119
  inhalation positive animal study
• Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
  2026 ・ J Transl Med ・ PMID 41654898
  mixed routes positive animal study
• Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report.
  2025 ・ Open Med (Wars) ・ PMID 41141928
  hydrogen-rich water positive human case report
• Optimized dose of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke.
  2025 ・ Brain Res ・ PMID 40935311
  hydrogen-rich water positive animal study
• Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults.
  2025 ・ Biogerontology ・ PMID 40044939
  hydrogen-rich water not assessed review
• Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.
  2024 ・ In Vivo ・ PMID 39477420
  hydrogen-rich water positive human case report
• Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial.
  2024 ・ Crit Care Med ・ PMID 39133068
  inhalation mixed human randomized controlled trial
• The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury.
  2024 ・ Int J Mol Sci ・ PMID 39063126
  mixed routes not assessed review
• Molecular Hydrogen: Emerging Treatment for Stroke Management.
  2023 ・ Chem Res Toxicol ・ PMID 37988743
  mixed routes not assessed review
• Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial.
  2023 ・ EClinicalMedicine ・ PMID 36969346
  inhalation mixed human randomized controlled trial
• Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.
  2023 ・ Mol Neurobiol ・ PMID 36567361
  mixed routes not assessed review
• Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway.
  2023 ・ J Neuroimmune Pharmacol ・ PMID 35895245
  inhalation positive animal study
• Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils.
  2022 ・ PLoS One ・ PMID 36574398
  injection / infusion positive animal study
• Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality?
  2022 ・ Int J Mol Sci ・ PMID 35743035
  mixed routes not assessed review
• Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.
  2021 ・ Curr Opin Crit Care ・ PMID 33769417
  inhalation not assessed review
• Molecular Hydrogen Application in Stroke: Bench to Bedside.
  2021 ・ Curr Pharm Des ・ PMID 32940172
  mixed routes not assessed review
• Longitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke in rats.
  2020 ・ Brain Res ・ PMID 32919984
  hydrogen-rich water positive animal study
• Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
  2020 ・ Sci Rep ・ PMID 32704088
  inhalation positive animal study
• Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial.
  2017 ・ Trials ・ PMID 29058596
  inhalation not assessed human randomized controlled trial
• Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.
  2017 ・ J Stroke Cerebrovasc Dis ・ PMID 28669654
  inhalation positive human randomized controlled trial
• Molecular Hydrogen as a Neuroprotective Agent.
  2017 ・ Curr Neuropharmacol ・ PMID 27281176
  mixed routes not assessed review
• Molecular hydrogen: a therapeutic antioxidant and beyond.
  2016 ・ Med Gas Res ・ PMID 28217294
  not specified not assessed review
• Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression.
  2016 ・ Neurochem Res ・ PMID 27386874
  injection / infusion positive animal study
• Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats.
  2015 ・ BMC Neurosci ・ PMID 25925889
  hydrogen-rich water positive animal study
• Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.
  2015 ・ Brain Res ・ PMID 25920370
  hydrogen-rich water positive animal study