子癇前症ラットモデル（RUPP）における分子状水素の複数の病態改善効果
Oxidative stress is a key contributor to preeclampsia pathogenesis. Using the reduced uterine perfusion pressure (RUPP) rat model, hydrogen-rich water (HW) was administered orally from gestational day 12 to 19. HW significantly lowered mean arterial pressure and increased fetal and placental weights. Maternal circulating levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and reactive oxygen species biomarkers declined, while vascular endothelial growth factor rose. Proteinuria and renal histology also improved. In vitro experiments using BeWo trophoblast cells showed that H2 suppressed hydrogen peroxide-induced sFlt-1 expression but not hypoxia-induced expression. In villous explants from preeclamptic women, H2 reduced sFlt-1 expression, whereas explants from normotensive pregnancies were unaffected. Collectively, prophylactic H2 administration attenuated placental ischemia-driven hypertension, angiogenic imbalance, and oxidative stress in this model.
H2 is proposed to scavenge reactive oxygen species, thereby suppressing oxidative stress-driven sFlt-1 overexpression, restoring angiogenic balance, and reducing hypertension in placental ischemia conditions.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/27789293