分子状水素による涙液分泌促進および涙腺保護効果：ヒトおよびマウスを対象としたランダム化クロスオーバー試験
Dry eye disease, driven by aging and widespread digital device use, involves tear-film instability and osmotic stress-induced inflammation. This randomized crossover study examined whether a sustained hydrogen-generating supplement could address both pathologies. In 10 human participants, oral supplementation significantly elevated exhaled H2 concentration (p<0.01), improved tear stability (p<0.01), and reduced dry eye symptoms (p<0.05). Parallel mouse experiments demonstrated that H2 administration significantly increased tear secretion in healthy animals (p<0.05) and suppressed tear volume reduction in a murine dry eye model (p=0.007). The findings suggest that molecular hydrogen may simultaneously target tear-film instability and lacrimal gland dysfunction, warranting larger-scale investigation.
Molecular hydrogen is proposed to protect lacrimal gland tissue and stimulate tear secretion, thereby simultaneously addressing tear-film instability and osmotic stress-driven inflammation in the ocular surface.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/33742060