パクリタキセル誘発性末梢神経障害に伴う認知・情動障害に対する水素富化水の効果：マウスモデルによる検討
Using male mice administered paclitaxel (PTX) to model chemotherapy-induced peripheral neuropathy (PIPN), this study evaluated the effects of hydrogen-rich water (HRW) on pain and neuropsychiatric comorbidities. HRW given once or twice daily for 3–7 consecutive days reduced mechanical and thermal allodynia. Kv7 potassium channels and the Nrf2–heme oxygenase-1–NQO1 antioxidant pathway were implicated in these analgesic effects. HRW also suppressed memory impairment and anxiety- and depressive-like behaviors associated with PIPN. In the prefrontal cortex, HRW normalized elevated p-ERK1/2, p-Akt, and 4-hydroxynonenal levels while enhancing antioxidant enzyme activity. These findings suggest HRW may be a safe and effective candidate for addressing both the nociceptive and cognitive-emotional dimensions of PIPN.
HRW exerts analgesic effects via Kv7 potassium channel modulation and activates the Nrf2–heme oxygenase-1–NQO1 pathway to reduce oxidative stress, thereby normalizing elevated p-ERK1/2, p-Akt, and 4-HNE in the prefrontal cortex.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/36552595