ナノバイオ触媒による時空間的水素送達が誘導する休眠増強型触媒腫瘍抑制
A platinum-incorporated metal-organic framework (PM) was engineered to address colorectal cancer by combining light-triggered hydrogen generation with 5-aminosalicylic acid (5-ASA) co-delivery. Photocatalytic water splitting produces molecular hydrogen in a spatiotemporally controlled manner, disrupting intracellular redox balance and inducing a tumor dormancy state marked by cell cycle arrest and metabolic quiescence. Concurrently released 5-ASA blocks NF-κB nuclear translocation, preventing dormancy escape and remodeling the immunosuppressive tumor microenvironment. Decomposition of PM at the tumor site generates photosensitizers that amplify reactive oxygen species production, coupling hydrogen-driven dormancy with ROS-mediated cytotoxicity. The redox-inflammatory axis governed by the hydrogen/5-ASA interaction was mechanistically characterized through multiomics profiling across three tumor models and clinical specimens, demonstrating coordinated cell cycle control and microenvironmental reprogramming as a strategy against colorectal cancer progression.
Photocatalytic water splitting generates H2 that induces tumor dormancy via cell cycle arrest and metabolic quiescence; co-released 5-ASA suppresses NF-κB nuclear translocation to prevent dormancy escape; PM decomposition products act as photosensitizers amplifying ROS storms, synergizing H2-driven dormancy with oxidative cytotoxicity.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/40931918