空洞埋め込み型二重円錐マイクロニードルを用いた乾癬への経皮的水素送達システムの開発
Psoriasis is a chronic inflammatory skin condition driven by a self-reinforcing cycle of oxidative stress and immune dysregulation. Conventional topical agents face barriers from limited skin permeability and systemic side-effect risks. In this study, a double-conical microneedle device with embedded cavities was engineered to carry MgH₂ powders and achieve sustained intracutaneous release of molecular hydrogen. In a murine psoriasis model, the system outperformed calcipotriol cream—a standard-of-care topical agent—by substantially reducing oxidative tissue damage, pro-inflammatory cytokine levels, immune cell infiltration, keratinocyte hyperproliferation, and systemic manifestations. Mechanistic analyses clarified how the oxidative stress–inflammation axis perpetuates psoriatic pathology. The findings establish a microneedle-based transdermal platform as a viable strategy for delivering molecular hydrogen to inflammatory skin conditions.
MgH₂ embedded in microneedles releases molecular hydrogen within skin tissue, selectively scavenging reactive oxygen species and interrupting the mutually reinforcing oxidative stress–inflammation cycle, thereby suppressing keratinocyte hyperproliferation and immune cell infiltration.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/41083007