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Clinical applications of hydrogen inhalation

Human clinical studies of hydrogen inhalation (randomized trials, observational studies, case reports). Delivery is restricted to inhalation; consult the safety notes separately.

Related papers (34)

• Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study.
  Can J Physiol Pharmacol 2026 — human randomized controlled trial — inhalation — mixed
• Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
  Sci Rep 2026 — human observational study — inhalation — positive
• [The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome].
  Ter Arkh 2026 — human randomized controlled trial — inhalation — positive
• Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study.
  Med Gas Res 2025 — human randomized controlled trial — inhalation — positive
• Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized controlled trial.
  Front Pharmacol 2025 — human randomized controlled trial — inhalation — mixed
• [Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period].
  Ter Arkh 2025 — human randomized controlled trial — inhalation — positive
• Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy.
  Adv Radiat Oncol 2025 — human randomized controlled trial — inhalation — positive
• Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.
  In Vivo 2024 — human case report — inhalation — positive
• [Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen].
  Ter Arkh 2024 — human randomized controlled trial — inhalation — positive
• The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study.
  Free Radic Biol Med 2024 — human randomized controlled trial — inhalation — positive
• Hinhalation therapy in patients with moderate COVID-19 (HCOVID): a prospective ascending-dose phase I clinical trial.
  Antimicrob Agents Chemother 2024 — human case report — inhalation — positive
• Realizing brain therapy with "smart medicine": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.
  Med Gas Res 2024 — human case report — inhalation — positive
• Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial.
  Crit Care Med 2024 — human randomized controlled trial — inhalation — mixed
• Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study.
  Med Gas Res 2023 — human randomized controlled trial — inhalation — positive
• Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial.
  EClinicalMedicine 2023 — human randomized controlled trial — inhalation — mixed
• Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial.
  Antioxidants (Basel) 2023 — human observational study — inhalation — positive
• The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial.
  J Clin Biochem Nutr 2023 — human randomized controlled trial — inhalation — positive
• Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation.
  Int J Environ Res Public Health 2022 — human randomized controlled trial — inhalation — positive
• Hydrogen Gas Inhalation Regressed Coronary Artery Aneurysm in Kawasaki Disease-Case Report and Article Review.
  Front Cardiovasc Med 2022 — human case report — inhalation — positive
• Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.
  Bull Exp Biol Med 2022 — human observational study — inhalation — positive
• Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study.
  Med Gas Res 2021 — human observational study — inhalation — positive
• Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study.
  Neurol Sci 2021 — human randomized controlled trial — inhalation — null
• Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass.
  Sovrem Tekhnologii Med 2021 — human observational study — inhalation — positive
• Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.
  Trials 2021 — human randomized controlled trial — inhalation — not assessed
• Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.
  Med Gas Res 2020 — human randomized controlled trial — inhalation — positive
• Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome.
  J Clin Biochem Nutr 2020 — human case report — inhalation — mixed
• Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men.
  Med Gas Res 2020 — human randomized controlled trial — inhalation — mixed
• Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease.
  Med Gas Res 2018 — human randomized controlled trial — inhalation — null
• The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　- First Pilot Study in Humans.
  Circ J 2017 — human observational study — inhalation — mixed
• Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.
  J Stroke Cerebrovasc Dis 2017 — human randomized controlled trial — inhalation — positive
• Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial.
  Trials 2017 — human randomized controlled trial — inhalation — not assessed
• Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.
  Adv Exp Med Biol 2013 — human observational study — inhalation — not assessed
• A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level.
  Med Gas Res 2012 — human case report — inhalation — positive
• [Temporary clipping and cerebral blood flow in patients with cerebral aneurysms].
  Zh Vopr Neirokhir Im N N Burdenko 2006 — human observational study — inhalation — not assessed

Related safety notes

• inhalation-concentration
• lineage