H₂
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immune modulation
180 papers
Delivery-method distribution
hydrogen-rich water: 61
mixed routes: 33
inhalation: 29
not specified: 20
in vitro: 17
injection / infusion: 10
topical application: 4
animal model: 4
hydrogen bath: 2
Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report.
2025 ・ In Vivo ・ PMID 39740897
hydrogen-rich water
positive
human case report
Thermally processed rice starch impacts glucose homeostasis in mice to different degrees via disturbing gut microbial structure and intestinal barrier function.
2025 ・ Carbohydr Polym ・ PMID 39562071
not specified
not assessed
animal study
Synergistic Antioxidant Effects of Molecular Hydrogen and Cold Atmospheric Plasma in Enhancing Mesenchymal Stem Cell Therapy.
2024 ・ Antioxidants (Basel) ・ PMID 39765910
mixed routes
not assessed
review
Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model.
2024 ・ Antioxidants (Basel) ・ PMID 39594470
inhalation
positive
animal study
Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.
2024 ・ In Vivo ・ PMID 39477420
hydrogen-rich water
positive
human case report
Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.
2024 ・ In Vivo ・ PMID 39477378
hydrogen-rich water
positive
human case report
The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension.
2024 ・ Int J Mol Sci ・ PMID 39456794
inhalation
positive
animal study
Au/Ag@ZnS yolk-shell photocatalysts enhanced with noble metals and hyaluronic acid for efficient hydrogen production in rheumatoid arthritis therapy.
2024 ・ Int J Biol Macromol ・ PMID 39322151
in vitro
positive
in vitro study
Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial.
2024 ・ Heliyon ・ PMID 39258191
hydrogen-rich water
positive
human randomized controlled trial
Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study.
2024 ・ Biomedicines ・ PMID 39200347
in vitro
positive
in vitro study
Molecular hydrogen supplementation in mice ameliorates lipopolysaccharide-induced loss of interest.
2024 ・ PCN Rep ・ PMID 39171191
hydrogen-rich water
mixed
animal study
Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.
2024 ・ Free Radic Biol Med ・ PMID 39147072
hydrogen-rich water
positive
animal study
Molecular Hydrogen for Outpatients with COVID-19 (Hydro-COVID): A Phase 3 Randomised, Triple-Blinded, Pragmatic, Placebo-Controlled, Multicentre Trial.
2024 ・ J Clin Med ・ PMID 39124575
hydrogen-rich water
null
human randomized controlled trial
A novel intervention of molecular hydrogen on the unbalance of the gut microbiome in opioid addiction: Experimental and human studies.
2024 ・ Biomed Pharmacother ・ PMID 39116782
mixed routes
positive
other
Hinhalation therapy in patients with moderate COVID-19 (HCOVID): a prospective ascending-dose phase I clinical trial.
2024 ・ Antimicrob Agents Chemother ・ PMID 39016593
inhalation
positive
human case report
An ethically guided preclinical device for phenotyping H2 production in laboratory rodents.
2024 ・ Animal Model Exp Med ・ PMID 38925626
not specified
not assessed
animal study
Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.
2024 ・ In Vivo ・ PMID 38688598
inhalation
positive
human case report
Mesenchymal Stem Cell Priming: Potential Benefits of Administration of Molecular Hydrogen.
2024 ・ Pharmaceuticals (Basel) ・ PMID 38675429
mixed routes
not assessed
review
Prospects of molecular hydrogen in cancer prevention and treatment.
2024 ・ J Cancer Res Clin Oncol ・ PMID 38555538
mixed routes
not assessed
review
The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial.
2024 ・ BMC Womens Health ・ PMID 38532373
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen-rich water supplementation improves metabolic profile during peripartum period in Gurcu goats and enhances the health and survival of kids.
2024 ・ Res Vet Sci ・ PMID 38458045
hydrogen-rich water
mixed
animal study
Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing.
2024 ・ Natl Sci Rev ・ PMID 38213516
topical application
positive
animal study
Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.
2023 ・ Biomedicines ・ PMID 38137362
inhalation
mixed
animal study
The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial.
2023 ・ J Clin Biochem Nutr ・ PMID 37970554
inhalation
positive
human randomized controlled trial
Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults.
2023 ・ Nutrition ・ PMID 37734117
hydrogen-rich water
positive
human observational study
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