H₂
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reactive oxygen species
774 papers
Delivery-method distribution
hydrogen-rich water: 224
in vitro: 135
inhalation: 133
mixed routes: 118
not specified: 75
injection / infusion: 58
topical application: 14
animal model: 12
hydrogen bath: 5
Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
2016 ・ Biochim Biophys Acta ・ PMID 26488087
in vitro
positive
in vitro study
Hydrogen-rich water-alleviated ultraviolet-B-triggered oxidative damage is partially associated with the manipulation of the metabolism of (iso)flavonoids and antioxidant defence in Medicago sativa.
2015 ・ Funct Plant Biol ・ PMID 32480752
hydrogen-rich water
positive
other
[Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury].
2015 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 27132459
injection / infusion
positive
animal study
Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study.
2015 ・ Antioxidants (Basel) ・ PMID 26783840
hydrogen-rich water
positive
human observational study
Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats.
2015 ・ Invest Ophthalmol Vis Sci ・ PMID 26720481
injection / infusion
positive
animal study
Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation.
2015 ・ Bioorg Med Chem ・ PMID 26596710
in vitro
positive
in vitro study
[Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases].
2015 ・ Seikagaku ・ PMID 26571560
mixed routes
not assessed
review
Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury.
2015 ・ J Clin Biochem Nutr ・ PMID 26566302
hydrogen-rich water
positive
animal study
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw.
2015 ・ Ther Clin Risk Manag ・ PMID 26508867
injection / infusion
not assessed
letter
Intravenous infusion of H2-saline suppresses oxidative stress and elevates antioxidant potential in Thoroughbred horses after racing exercise.
2015 ・ Sci Rep ・ PMID 26493164
injection / infusion
positive
animal study
Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.
2015 ・ Med Gas Res ・ PMID 26483953
mixed routes
not assessed
review
Cadmium-Induced Hydrogen Accumulation Is Involved in Cadmium Tolerance in Brassica campestris by Reestablishment of Reduced Glutathione Homeostasis.
2015 ・ PLoS One ・ PMID 26445361
hydrogen-rich water
positive
in vitro study
Lyophilization protects [FeFe]-hydrogenases against O2-induced H-cluster degradation.
2015 ・ Sci Rep ・ PMID 26364994
in vitro
positive
in vitro study
Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
2015 ・ Toxicol Lett ・ PMID 26276082
in vitro
positive
in vitro study
Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.
2015 ・ Chem Biol Interact ・ PMID 26271894
in vitro
positive
in vitro study
Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.
2015 ・ Int Immunopharmacol ・ PMID 26253656
in vitro
positive
in vitro study
Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.
2015 ・ Free Radic Biol Med ・ PMID 26117323
mixed routes
positive
animal study
The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats.
2015 ・ PLoS One ・ PMID 26103048
mixed routes
positive
animal study
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
2015 ・ J Thorac Cardiovasc Surg ・ PMID 26095621
hydrogen-rich water
positive
animal study
Michael acceptor in gambogic acid--Its role and application for potent antitumor agents.
2015 ・ Bioorg Med Chem Lett ・ PMID 26009165
in vitro
mixed
in vitro study
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.
2015 ・ Cardiovasc Pathol ・ PMID 25979689
hydrogen-rich water
positive
animal study
Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury.
2015 ・ Free Radic Res ・ PMID 25947958
mixed routes
positive
animal study
Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
2015 ・ Mol Med Rep ・ PMID 25936373
mixed routes
positive
human case report
Molecular hydrogen: An inert gas turns clinically effective.
2015 ・ Ann Med ・ PMID 25936365
mixed routes
not assessed
review
Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats.
2015 ・ BMC Neurosci ・ PMID 25925889
hydrogen-rich water
positive
animal study
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