抗腫瘍剤としての分子状水素：遺伝子発現調節を介した作用機序の考察
This review examines the antitumor potential and safety profile of molecular hydrogen (H₂). Cancer development is closely linked to mutations in both nuclear DNA and mitochondrial DNA (mtDNA), with hydroxyl radicals (·OH)—among the most potent oxidizing reactive oxygen species—identified as a key causative factor. H₂ selectively neutralizes ·OH and, unlike conventional antitumor agents, appears to lack significant side effects. Beyond direct radical scavenging, evidence suggests that H₂ may engage indirect biological defense pathways through modulation of gene expression. The review also addresses findings on H₂ efficacy in reducing adverse effects associated with cancer-related interventions, consolidating current knowledge on its mechanistic basis as a candidate antitumor agent.
H₂ selectively scavenges hydroxyl radicals (·OH), thereby reducing oxidative DNA mutations in both nuclear and mitochondrial DNA. Additionally, indirect biological defense mechanisms involving gene expression regulation are proposed as contributing pathways.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/34445428