がん管理における分子状水素の役割：システマティックレビュー
This systematic review examined 677 articles retrieved from Cochrane, PubMed, and Google Scholar, ultimately selecting 27 studies meeting eligibility criteria to evaluate the effects of molecular hydrogen (H2) on cancer. H2 has been reported to exert anti-proliferative, antioxidative, pro-apoptotic, and anti-tumoral actions across diverse cancer types and administration routes. Findings were notably consistent regardless of study design or H2 delivery method. The compiled evidence suggests that H2, whether used alone or as an adjunct to existing regimens, is associated with improvements in patient survivability, quality of life, blood parameters, and tumor reduction. The authors conclude that, while more rigorous research is warranted, H2 represents a potentially valuable complement to current oncological approaches.
H2 is proposed to exert its anti-cancer effects primarily through selective scavenging of reactive oxygen species, thereby reducing oxidative stress and promoting apoptosis while suppressing tumor cell proliferation.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/36708550