神経膠芽腫に対する分子状水素とプロトンの抗腫瘍活性：非典型的な薬理学的考察
This review examines the antitumor properties of molecular hydrogen (H2) and protons (H+) with a focus on glioblastoma (GBM). H2 exhibits antioxidant, anti-inflammatory, and antiapoptotic characteristics that have been documented across multiple experimental and clinical investigations. In animal models, H2 inhalation suppressed GBM tumor growth and prolonged survival in tumor-bearing mice. At the cellular level, H2 reduced the sphere-forming capacity of glioma cells and inhibited their migration, invasion, and colony formation. Separately, proton beam radiotherapy was noted to offer certain advantages over conventional photon-based conformal approaches for central nervous system malignancies. The review highlights an emerging pharmacological framework in which both H2 and proton-based modalities may contribute to GBM management.
H2 selectively scavenges free radicals and is proposed to suppress glioma cell proliferation, migration, and invasion through antioxidant, anti-inflammatory, and antiapoptotic pathways.
For inhalation applications of molecular hydrogen, the lower flammability limit (LFL) deserves careful handling. The classical 4% figure applies to closed-system mixtures; the practical inhalation-environment threshold is 10%. Even pure-hydrogen output (the UFL 75% paradox) passes through the flammable range at the air–gas boundary. High-concentration (66% / 100%) inhalers are documented in the Japanese Consumer Affairs Agency accident-information database and are not recommended.
See also:
https://h2-papers.org/en/papers/37626524