水素富化透析液を用いた血液透析が透析関連疲労とエネルギー代謝に与える影響
Hemodialysis using electrolysis-generated hydrogen-enriched dialysate (E-HD) has been associated with reduced dialysis-related fatigue, yet its relationship to metabolic changes remained poorly understood. A total of 81 patients on standard hemodialysis were categorized into three groups based on fatigue severity and activity impact, then followed for 12 months after switching to E-HD. Patients with fatigue accompanied by activity reduction showed significant fatigue improvement, along with reductions in body fat and gains in skeletal muscle mass despite stable body weight. Enrichment analysis identified baseline differences in fatty acid metabolism, the citric acid cycle, and glycolysis between the highest-fatigue and no-fatigue groups; these metabolic disparities diminished following E-HD. The findings suggest that E-HD may reduce dialysis-related fatigue partly through modulation of energy metabolic pathways in uremic patients.
E-HD may alleviate dialysis-related fatigue by normalizing disrupted energy metabolism pathways—including fatty acid oxidation, the citric acid cycle, and glycolysis—observed in fatigued uremic patients at baseline.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/39934143