H₂
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apoptosis regulation
280 papers
Delivery-method distribution
mixed routes: 61
hydrogen-rich water: 61
inhalation: 53
in vitro: 47
injection / infusion: 29
not specified: 22
topical application: 5
hydrogen bath: 1
animal model: 1
Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats.
2017 ・ Neuroreport ・ PMID 28926473
inhalation
positive
animal study
Accelerated healing of full thickness dermal wounds by macroporous waterborne polyurethane-chitosan hydrogel scaffolds.
2017 ・ Mater Sci Eng C Mater Biol Appl ・ PMID 28887957
topical application
positive
animal study
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
2017 ・ Biochem Biophys Res Commun ・ PMID 28807355
hydrogen-rich water
positive
animal study
Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury due to intestinal intussusception in a rat model.
2017 ・ Med Gas Res ・ PMID 28744362
injection / infusion
positive
animal study
Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells.
2017 ・ Med Gas Res ・ PMID 28744359
in vitro
mixed
in vitro study
Hydrogen-rich medium protects mouse embryonic fibroblasts from oxidative stress by activating LKB1-AMPK-FoxO1 signal pathway.
2017 ・ Biochem Biophys Res Commun ・ PMID 28743498
in vitro
positive
in vitro study
Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats.
2017 ・ Neuroreport ・ PMID 28614179
inhalation
positive
animal study
Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.
2017 ・ PLoS One ・ PMID 28467497
in vitro
positive
in vitro study
Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β Induced Sirt1.
2017 ・ Biol Pharm Bull ・ PMID 28458345
hydrogen-rich water
positive
animal study
Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.
2017 ・ Oxid Med Cell Longev ・ PMID 28243358
hydrogen-rich water
positive
animal study
Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.
2017 ・ Shock ・ PMID 28234792
inhalation
positive
animal study
A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.
2017 ・ Gene ・ PMID 28189762
in vitro
not assessed
in vitro study
Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.
2017 ・ BMC Musculoskelet Disord ・ PMID 28148301
injection / infusion
positive
animal study
Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury.
2017 ・ Shock ・ PMID 27918369
hydrogen-rich water
positive
animal study
Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.
2017 ・ J Microbiol Biotechnol ・ PMID 27780950
in vitro
positive
in vitro study
Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice.
2017 ・ Redox Rep ・ PMID 26866650
hydrogen-rich water
positive
animal study
[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].
2016 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 29923387
injection / infusion
positive
animal study
Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy.
2016 ・ J Physiol Pharmacol ・ PMID 28011948
inhalation
positive
animal study
Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida 3.
2016 ・ Chin Med J (Engl) ・ PMID 27647193
hydrogen-rich water
positive
animal study
Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals.
2016 ・ Physiol Res ・ PMID 27643933
mixed routes
not assessed
review
Molecular hydrogen suppresses activated Wnt/β-catenin signaling.
2016 ・ Sci Rep ・ PMID 27558955
mixed routes
positive
in vitro study
Nitric oxide is involved in hydrogen gas-induced cell cycle activation during adventitious root formation in cucumber.
2016 ・ BMC Plant Biol ・ PMID 27352869
hydrogen-rich water
positive
in vitro study
Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice.
2016 ・ J Neuroimmunol ・ PMID 27138092
hydrogen-rich water
positive
animal study
Effects of hydrogen-rich water on depressive-like behavior in mice.
2016 ・ Sci Rep ・ PMID 27026206
hydrogen-rich water
positive
animal study
Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain.
2016 ・ Sci Rep ・ PMID 26905012
inhalation
positive
animal study
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