H₂
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apoptosis regulation
280 papers
Delivery-method distribution
mixed routes: 61
hydrogen-rich water: 61
inhalation: 53
in vitro: 47
injection / infusion: 29
not specified: 22
topical application: 5
hydrogen bath: 1
animal model: 1
Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications.
2025 ・ Curr Pharm Des ・ PMID 39810534
hydrogen-rich water
not assessed
review
Molecular hydrogen inhibits neuroinflammation and ameliorates depressive-like behaviors and short-term cognitive impairment in senescence-accelerated mouse prone 8 mice.
2025 ・ Behav Brain Res ・ PMID 39522774
hydrogen-rich water
positive
animal study
Molecular hydrogen gas and its therapeutic potential in recent disease progression.
2025 ・ Med Gas Res ・ PMID 39436178
not specified
not assessed
review
Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.
2025 ・ Biomaterials ・ PMID 39426122
in vitro
positive
in vitro study
Hydrogen as an innovative nootropic in health and disease.
2025 ・ Nutr Health ・ PMID 39042916
mixed routes
not assessed
review
Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis.
2024 ・ Front Aging Neurosci ・ PMID 39839307
hydrogen-rich water
positive
animal study
Combating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water.
2024 ・ Tissue Cell ・ PMID 39531856
hydrogen-rich water
positive
animal study
Au/Ag@ZnS yolk-shell photocatalysts enhanced with noble metals and hyaluronic acid for efficient hydrogen production in rheumatoid arthritis therapy.
2024 ・ Int J Biol Macromol ・ PMID 39322151
in vitro
positive
in vitro study
Molecular Hydrogen for Outpatients with COVID-19 (Hydro-COVID): A Phase 3 Randomised, Triple-Blinded, Pragmatic, Placebo-Controlled, Multicentre Trial.
2024 ・ J Clin Med ・ PMID 39124575
hydrogen-rich water
null
human randomized controlled trial
The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury.
2024 ・ Int J Mol Sci ・ PMID 39063126
mixed routes
not assessed
review
Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation.
2024 ・ Biomedicines ・ PMID 39062164
mixed routes
not assessed
review
The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice.
2024 ・ Antioxidants (Basel) ・ PMID 39061924
hydrogen-rich water
positive
animal study
Hydrogen alleviates hypoxic-ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes.
2024 ・ J Cell Mol Med ・ PMID 39001579
hydrogen-rich water
positive
animal study
Light-Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions.
2024 ・ Adv Sci (Weinh) ・ PMID 38924679
in vitro
positive
animal study
Mitigating radiation-induced brain injury via NLRP3/NLRC4/Caspase-1 pyroptosis pathway: Efficacy of memantine and hydrogen-rich water.
2024 ・ Biomed Pharmacother ・ PMID 38906028
hydrogen-rich water
positive
animal study
Inhalation of hydrogen gas mitigates sevoflurane-induced neuronal apoptosis in the neonatal cortex and is associated with changes in protein phosphorylation.
2024 ・ J Neurochem ・ PMID 38849977
inhalation
positive
animal study
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
2024 ・ Sci Rep ・ PMID 38745034
mixed routes
positive
animal study
Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.
2024 ・ In Vivo ・ PMID 38688598
inhalation
positive
human case report
Mesenchymal Stem Cell Priming: Potential Benefits of Administration of Molecular Hydrogen.
2024 ・ Pharmaceuticals (Basel) ・ PMID 38675429
mixed routes
not assessed
review
Decoupling the mutual promotion of inflammation and oxidative stress mitigates cognitive decline and depression-like behavior in rmTBI mice by promoting myelin renewal and neuronal survival.
2024 ・ Biomed Pharmacother ・ PMID 38479178
hydrogen-rich water
positive
animal study
Identification ofas a Susceptibility Gene for Familial Non-Medullary Thyroid Carcinoma.
2024 ・ Thyroid ・ PMID 38411500
in vitro
not assessed
other
Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy.
2024 ・ BMC Anesthesiol ・ PMID 38395800
inhalation
positive
animal study
Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review.
2024 ・ Int J Mol Sci ・ PMID 38256045
hydrogen-rich water
mixed
meta-analysis
The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis.
2023 ・ Asian Pac J Cancer Prev ・ PMID 38156844
in vitro
positive
in vitro study
Hyperbaric hydrogen therapy improves secondary brain injury after head trauma.
2023 ・ Undersea Hyperb Med ・ PMID 38055881
inhalation
positive
animal study
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