H₂
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hydroxyl radical scavenging
352 papers
Delivery-method distribution
hydrogen-rich water: 93
mixed routes: 71
inhalation: 66
in vitro: 41
injection / infusion: 34
not specified: 31
topical application: 9
animal model: 7
The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans.
2017 ・ Circ J ・ PMID 28321000
inhalation
mixed
human observational study
Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.
2017 ・ Oxid Med Cell Longev ・ PMID 28243358
hydrogen-rich water
positive
animal study
Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.
2017 ・ BMC Musculoskelet Disord ・ PMID 28148301
injection / infusion
positive
animal study
Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ.
2017 ・ Mol Med Rep ・ PMID 28098910
injection / infusion
positive
animal study
Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment.
2017 ・ Hum Cell ・ PMID 27804028
in vitro
positive
in vitro study
Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.
2017 ・ J Microbiol Biotechnol ・ PMID 27780950
in vitro
positive
in vitro study
Hydrogen-rich water regulates effects of ROS balance on morphology, growth and secondary metabolism via glutathione peroxidase in Ganoderma lucidum.
2017 ・ Environ Microbiol ・ PMID 27554678
in vitro
positive
in vitro study
Molecular hydrogen: a therapeutic antioxidant and beyond.
2016 ・ Med Gas Res ・ PMID 28217294
not specified
not assessed
review
Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy.
2016 ・ J Physiol Pharmacol ・ PMID 28011948
inhalation
positive
animal study
Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress.
2016 ・ Am J Transl Res ・ PMID 27830032
in vitro
positive
animal study
Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model.
2016 ・ Free Radic Biol Med ・ PMID 27789293
mixed routes
positive
animal study
The Clinical Application of Hydrogen as a Medical Treatment.
2016 ・ Acta Med Okayama ・ PMID 27777424
mixed routes
not assessed
review
Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice.
2016 ・ Oxid Med Cell Longev ・ PMID 27774116
animal model
positive
animal study
Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals.
2016 ・ Physiol Res ・ PMID 27643933
mixed routes
not assessed
review
The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production of Reactive Oxygen Species and TNF-α in Macrophages.
2016 ・ Inflammation ・ PMID 27624060
in vitro
positive
in vitro study
Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.
2016 ・ Med Sci Monit ・ PMID 27606690
injection / infusion
not assessed
other
Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.
2016 ・ Circ J ・ PMID 27477846
in vitro
positive
in vitro study
Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression.
2016 ・ Neurochem Res ・ PMID 27386874
injection / infusion
positive
animal study
Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis.
2016 ・ PLoS One ・ PMID 27115738
mixed routes
positive
in vitro study
Effects of hydrogen-rich water on depressive-like behavior in mice.
2016 ・ Sci Rep ・ PMID 27026206
hydrogen-rich water
positive
animal study
Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain.
2016 ・ Sci Rep ・ PMID 26905012
inhalation
positive
animal study
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.
2016 ・ Sci Rep ・ PMID 26739257
in vitro
positive
in vitro study
Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.
2016 ・ Free Radic Biol Med ・ PMID 26709014
hydrogen-rich water
positive
animal study
Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.
2016 ・ Neurochem Res ・ PMID 26537817
injection / infusion
positive
animal study
Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
2016 ・ Biochim Biophys Acta ・ PMID 26488087
in vitro
positive
in vitro study
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