H₂
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mitochondrial function
226 papers
Delivery-method distribution
hydrogen-rich water: 55
in vitro: 46
mixed routes: 44
not specified: 34
inhalation: 24
injection / infusion: 15
animal model: 7
hydrogen bath: 1
Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.
2017 ・ PLoS One ・ PMID 28467497
in vitro
positive
in vitro study
Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson's Disease Model Mice.
2017 ・ Neurochem Res ・ PMID 28462451
hydrogen-rich water
positive
animal study
Does HAlter Mitochondrial Bioenergetics via GHS-R1α Activation?
2017 ・ Theranostics ・ PMID 28435468
not specified
not assessed
other
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.
2016 ・ NPJ Aging Mech Dis ・ PMID 28721265
hydrogen-rich water
positive
animal study
Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.
2016 ・ Med Sci Monit ・ PMID 27606690
injection / infusion
not assessed
other
Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis.
2016 ・ Oxid Med Cell Longev ・ PMID 27413421
mixed routes
not assessed
review
Hydrogen activation by [NiFe]-hydrogenases.
2016 ・ Biochem Soc Trans ・ PMID 27284053
in vitro
not assessed
review
Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer.
2016 ・ Biochem Pharmacol ・ PMID 26774456
hydrogen-rich water
positive
animal study
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.
2016 ・ Sci Rep ・ PMID 26739257
in vitro
positive
in vitro study
Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.
2016 ・ Neurochem Res ・ PMID 26537817
injection / infusion
positive
animal study
Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
2016 ・ Biochim Biophys Acta ・ PMID 26488087
in vitro
positive
in vitro study
Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats.
2015 ・ Invest Ophthalmol Vis Sci ・ PMID 26720481
injection / infusion
positive
animal study
Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.
2015 ・ Chem Biol Interact ・ PMID 26271894
in vitro
positive
in vitro study
The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats.
2015 ・ PLoS One ・ PMID 26103048
mixed routes
positive
animal study
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.
2015 ・ Cardiovasc Pathol ・ PMID 25979689
hydrogen-rich water
positive
animal study
Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina.
2015 ・ Clin Exp Ophthalmol ・ PMID 25801048
in vitro
positive
in vitro study
Targeting molecular hydrogen to mitochondria: barriers and gateways.
2015 ・ Pharmacol Res ・ PMID 25720951
not specified
not assessed
review
Stimulation of human damaged sperm motility with hydrogen molecule.
2015 ・ Med Gas Res ・ PMID 25649433
in vitro
positive
in vitro study
Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats.
2015 ・ Anesthesiology ・ PMID 25501899
injection / infusion
positive
animal study
Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management.
2014 ・ Circulation ・ PMID 25366995
inhalation
positive
animal study
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
2014 ・ PLoS One ・ PMID 25251220
hydrogen-rich water
positive
animal study
Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats.
2014 ・ Toxicol Appl Pharmacol ・ PMID 24967689
hydrogen-rich water
positive
animal study
Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.
2014 ・ Pharmacol Ther ・ PMID 24769081
mixed routes
not assessed
review
Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats.
2014 ・ Mol Cell Biochem ・ PMID 24652103
hydrogen-rich water
positive
animal study
Hydrogen-rich water delays postharvest ripening and senescence of kiwifruit.
2014 ・ Food Chem ・ PMID 24629944
hydrogen-rich water
positive
other
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