放射線防護剤としての分子状水素の可能性：科学的・臨床的進展のレビュー
The majority of ionizing radiation-induced biological damage originates from hydroxyl radicals (·OH) generated through water radiolysis. Molecular hydrogen (H2) selectively scavenges ·OH and peroxynitrite (ONOO⁻), conferring antioxidant protection. This review consolidates evidence from in vitro and in vivo studies demonstrating H2's radioprotective properties, including findings from a randomized, placebo-controlled trial in which hydrogen-rich water consumption reduced radiation-induced oxidative stress responses without diminishing anti-tumor efficacy. Because H2 gas carries explosion risk, hydrogen-saturated solutions—such as physiological saline or pure water—are considered more practical for routine use. The review surveys key scientific and clinical progress supporting hydrogen-rich solutions as a novel class of radioprotective agents.
H2 selectively neutralizes hydroxyl radicals (·OH) and peroxynitrite (ONOO⁻) produced during water radiolysis, thereby reducing oxidative damage to biomolecules caused by ionizing radiation.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/24155664