H₂
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Inhalation
Hydrogen water
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Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases.
2013 ・ Curr Pharm Des ・ PMID 23859555
mixed routes
not assessed
review
Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.
2013 ・ Adv Exp Med Biol ・ PMID 23852510
inhalation
not assessed
human observational study
Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water.
2013 ・ J Hazard Mater ・ PMID 23846121
hydrogen-rich water
positive
in vitro study
Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.
2013 ・ Int J Ophthalmol ・ PMID 23826519
in vitro
positive
in vitro study
Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.
2013 ・ Med Gas Res ・ PMID 23816239
injection / infusion
positive
human case report
Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation.
2013 ・ Int J Radiat Biol ・ PMID 23786587
in vitro
positive
in vitro study
Protective effects of hydrogen-rich saline on ulcerative colitis rat model.
2013 ・ J Surg Res ・ PMID 23773716
injection / infusion
positive
animal study
Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.
2013 ・ Med Gas Res ・ PMID 23742229
not specified
not assessed
review
1-(3-Chloro-phen-yl)-5-(2,4-di-hydroxy-benzo-yl)pyridin-2(1H)-one.
2013 ・ Acta Crystallogr Sect E Struct Rep Online ・ PMID 23723884
not specified
not assessed
other
The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance.
2013 ・ Med Gas Res ・ PMID 23680032
mixed routes
not assessed
review
The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion.
2013 ・ Acta Neurochir Suppl ・ PMID 23564105
inhalation
positive
animal study
Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells.
2013 ・ Med Gas Res ・ PMID 23448206
in vitro
positive
in vitro study
Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.
2013 ・ Mol Neurobiol ・ PMID 23436141
not specified
not assessed
review
Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.
2013 ・ Mov Disord ・ PMID 23400965
hydrogen-rich water
positive
human randomized controlled trial
Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.
2013 ・ Urology ・ PMID 23374763
hydrogen-rich water
null
human randomized controlled trial
Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production.
2013 ・ Dig Dis Sci ・ PMID 23371012
mixed routes
positive
animal study
A novel method of preserving cardiac grafts using a hydrogen-rich water bath.
2013 ・ J Heart Lung Transplant ・ PMID 23273745
hydrogen bath
positive
animal study
Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.
2013 ・ Anesthesiology ・ PMID 23221861
inhalation
positive
animal study
Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.
2013 ・ Mol Cell Biochem ・ PMID 23212446
in vitro
positive
in vitro study
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.
2013 ・ Osteoporos Int ・ PMID 22648000
mixed routes
positive
animal study
H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model.
2012 ・ J Am Heart Assoc ・ PMID 23316300
inhalation
positive
animal study
6,8-Dihy-droxy-8a-methyl-3,5-dimethyl-idenedeca-hydro-naphtho-[2,3-b]furan-2(3H)-one.
2012 ・ Acta Crystallogr Sect E Struct Rep Online ・ PMID 23284548
not specified
not assessed
other
Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis.
2012 ・ Shock ・ PMID 23160520
inhalation
positive
animal study
Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.
2012 ・ Med Gas Res ・ PMID 23031079
hydrogen-rich water
positive
human observational study
Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines.
2012 ・ Brain Res ・ PMID 23010312
injection / infusion
positive
animal study
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