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Influence of hydrogen-rich water on spermatogenesis and sperm parameters in experimentally induced hypothyroidism and subclinical hypothyroidism models.
2026 ・ Reprod Toxicol ・ PMID 41421768
hydrogen-rich water
positive
animal study
Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study.
2026 ・ Can J Physiol Pharmacol ・ PMID 41401441
inhalation
mixed
human randomized controlled trial
Hydrogen gas promotes neuroprotection and upregulates ATF5 expression in neonatal hypoxic-ischemic brain injury.
2026 ・ Exp Neurol ・ PMID 41386344
inhalation
positive
animal study
Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling coupling.
2026 ・ Bioact Mater ・ PMID 41334374
in vitro
positive
in vitro study
Postharvest preservation of chestnuts: Combined application of hydrogen-rich water and a carboxymethyl chitosan/sodium alginate composite coating.
2026 ・ Int J Biol Macromol ・ PMID 41314584
hydrogen-rich water
positive
other
Therapeutic potential of magnesium diboride nanosheets in PAH-associated right heart failure: Integrated multi-omics analysis reveals ferroptosis suppression via LC3/ATG5/NCOA4/FTH1 pathway.
2026 ・ Free Radic Biol Med ・ PMID 41308938
in vitro
positive
animal study
Gas Therapies for Neuro-Protection.
2026 ・ Crit Care Clin ・ PMID 41260719
inhalation
not assessed
review
Advances in hydrogen delivery strategies for therapeutic applications.
2026 ・ Adv Drug Deliv Rev ・ PMID 41232804
mixed routes
not assessed
review
Hydrogen intervention attenuates chronic hypoxia-induced bone degeneration and multi-organ damage via modulation of the gut microbiota.
2026 ・ Bone ・ PMID 41224067
hydrogen-rich water
positive
animal study
Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.
2026 ・ J Nutr Biochem ・ PMID 41207540
hydrogen-rich water
positive
animal study
Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5-mediated autophagy.
2026 ・ Pain ・ PMID 41143867
hydrogen-rich water
positive
animal study
Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.
2026 ・ Med Gas Res ・ PMID 40826940
mixed routes
positive
review
Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.
2026 ・ Med Gas Res ・ PMID 40580185
hydrogen-rich water
positive
animal study
Hydrogen-rich water attenuates radiation-induced oral mucositis in mice via antioxidant and gut microbiota-stabilizing effects: a longitudinal study.
2025 ・ Gut Microbes Rep ・ PMID 41909889
hydrogen-rich water
positive
animal study
Hydrogen-Rich Water Potentiates Cannabinoid- and Gabapentinoid-Induced Analgesia in Neuropathic Pain.
2025 ・ Int J Mol Sci ・ PMID 41465581
hydrogen-rich water
positive
animal study
Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status.
2025 ・ Antioxidants (Basel) ・ PMID 41462618
inhalation
positive
animal study
Molecular Hydrogen Affords Similar Neuroprotection to Therapeutic Hypothermia in a Porcine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
2025 ・ Antioxidants (Basel) ・ PMID 41462605
inhalation
positive
animal study
Hydrogen rescues vascular endothelial cells in obstructive sleep apnea-hypopnea syndrome by modulating nitric oxide.
2025 ・ J Thorac Dis ・ PMID 41376930
mixed routes
positive
animal study
Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice.
2025 ・ J Tradit Chin Med ・ PMID 41376217
injection / infusion
positive
animal study
Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review.
2025 ・ Int J Mol Sci ・ PMID 41373725
mixed routes
not assessed
review
Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.
2025 ・ High Alt Med Biol ・ PMID 41371770
hydrogen-rich water
mixed
human randomized controlled trial
Molecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy.
2025 ・ Eur J Med Res ・ PMID 41351127
inhalation
positive
animal study
The Rieske iron-sulfur protein is a primary target of molecular hydrogen.
2025 ・ Redox Biol ・ PMID 41330217
mixed routes
positive
in vitro study
Efficacy of different nasal irrigation treatments versus placebo in allergic rhinitis: a systematic review and network meta-analysis.
2025 ・ Front Pharmacol ・ PMID 41293244
topical application
mixed
meta-analysis
Water-Promoted Molar-Level Photocatalysis and Spontaneous Product Separation with Near-Unity Quantum Efficiency.
2025 ・ J Am Chem Soc ・ PMID 41287352
in vitro
not assessed
in vitro study
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