H₂
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cancer chemo (side-effect)
47 papers
Delivery-method distribution
in vitro: 18
hydrogen-rich water: 13
mixed routes: 9
not specified: 3
inhalation: 3
injection / infusion: 1
Ru-Based NSAIDs as Potential Anticancer Therapeutics.
2026 ・ Molecules ・ PMID 41752368
in vitro
positive
in vitro study
Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy.
2026 ・ J Cell Mol Med ・ PMID 41702867
in vitro
positive
in vitro study
Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice.
2025 ・ J Tradit Chin Med ・ PMID 41376217
injection / infusion
positive
animal study
Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy.
2025 ・ Adv Radiat Oncol ・ PMID 41020280
inhalation
positive
human randomized controlled trial
Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy.
2025 ・ ACS Nano ・ PMID 40931918
in vitro
positive
in vitro study
Preventing Cisplatin-Induced Neuropathy and Related Emotional Disorders with the Coadministration of Duloxetine and Hydrogen-Rich Water in Male and Female Mice.
2025 ・ Antioxidants (Basel) ・ PMID 40867900
mixed routes
positive
animal study
Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.
2025 ・ ACS Appl Mater Interfaces ・ PMID 40864154
in vitro
positive
in vitro study
Integrating QSAR modeling, ADMET screening, molecular docking, and molecular dynamics simulations to identify potential MCF-7 inhibitors.
2025 ・ Comput Biol Med ・ PMID 40850177
in vitro
positive
in vitro study
Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism.
2025 ・ Mol Biol Rep ・ PMID 40705191
inhalation
positive
animal study
Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways.
2025 ・ Transl Androl Urol ・ PMID 40687659
hydrogen-rich water
positive
animal study
Molecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications.
2025 ・ Mol Biol Rep ・ PMID 40569354
not specified
not assessed
review
Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption.
2025 ・ Sci Rep ・ PMID 40181080
mixed routes
positive
animal study
Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.
2025 ・ Biomaterials ・ PMID 39426122
in vitro
positive
in vitro study
Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation.
2024 ・ Biomedicines ・ PMID 39062164
mixed routes
not assessed
review
The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice.
2024 ・ Antioxidants (Basel) ・ PMID 39061924
hydrogen-rich water
positive
animal study
Prospects of molecular hydrogen in cancer prevention and treatment.
2024 ・ J Cancer Res Clin Oncol ・ PMID 38555538
mixed routes
not assessed
review
Identification ofas a Susceptibility Gene for Familial Non-Medullary Thyroid Carcinoma.
2024 ・ Thyroid ・ PMID 38411500
in vitro
not assessed
other
The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis.
2023 ・ Asian Pac J Cancer Prev ・ PMID 38156844
in vitro
positive
in vitro study
A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice.
2023 ・ Antioxidants (Basel) ・ PMID 38136183
hydrogen-rich water
positive
animal study
Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application.
2023 ・ Cell Mol Life Sci ・ PMID 37269385
mixed routes
not assessed
review
A Systematic Review of Molecular Hydrogen Therapy in Cancer Management.
2023 ・ Asian Pac J Cancer Prev ・ PMID 36708550
mixed routes
positive
review
New Treatment for the Cognitive and Emotional Deficits Linked with Paclitaxel-Induced Peripheral Neuropathy in Mice.
2022 ・ Antioxidants (Basel) ・ PMID 36552595
hydrogen-rich water
positive
animal study
Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway.
2022 ・ Biomed Res Int ・ PMID 35528164
mixed routes
positive
in vitro study
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model.
2022 ・ World J Gastrointest Oncol ・ PMID 35116114
hydrogen-rich water
positive
animal study
A confined crosslinking strategy towards an intelligent organosilica-micellar hybrid drug delivery system.
2022 ・ Biomater Sci ・ PMID 34904973
in vitro
positive
in vitro study
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