H₂
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diabetes / metabolic syndrome
49 papers
Delivery-method distribution
hydrogen-rich water: 26
mixed routes: 7
not specified: 5
topical application: 4
injection / infusion: 3
inhalation: 2
in vitro: 1
animal model: 1
The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials.
2026 ・ Diabetol Metab Syndr ・ PMID 41888952
hydrogen-rich water
not assessed
meta-analysis
Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.
2026 ・ J Nutr Biochem ・ PMID 41207540
hydrogen-rich water
positive
animal study
Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways.
2025 ・ Transl Androl Urol ・ PMID 40687659
hydrogen-rich water
positive
animal study
Coaxial Fibrous Dressing Enabling Sequential NO/HRelease for Temporally Programmed Antibacterial and Healing-Promoting Functions in Infected Diabetic Wound Treatment.
2025 ・ ACS Appl Mater Interfaces ・ PMID 40504663
topical application
positive
animal study
Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus.
2025 ・ Curr Med Chem ・ PMID 40289982
hydrogen-rich water
not assessed
review
Hydrogen-rich water consumption modifies the chemical, biochemical, nutritional, and bioactive properties of the goat's colostrum and mature milk.
2025 ・ Food Chem ・ PMID 40112728
hydrogen-rich water
mixed
animal study
Hydrogen and Methane Detection in Breath in Response to Two Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Concentration in Obese Patients with Type 2 Diabetes and Normoglycemic Subjects.
2025 ・ Nutrients ・ PMID 40077785
not specified
mixed
human observational study
Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in mice.
2025 ・ Redox Biol ・ PMID 39752998
mixed routes
positive
animal study
Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report.
2025 ・ In Vivo ・ PMID 39740897
hydrogen-rich water
positive
human case report
Thermally processed rice starch impacts glucose homeostasis in mice to different degrees via disturbing gut microbial structure and intestinal barrier function.
2025 ・ Carbohydr Polym ・ PMID 39562071
not specified
not assessed
animal study
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis.
2024 ・ Int J Endocrinol Metab ・ PMID 39839806
hydrogen-rich water
mixed
meta-analysis
Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice.
2024 ・ Transl Vis Sci Technol ・ PMID 39446362
hydrogen-rich water
positive
animal study
Inhalation of H/O(66.7 %/33.3 %) mitigates depression-like behaviors in diabetes mellitus complicated with depression mice via suppressing inflammation and preventing hippocampal damage.
2024 ・ Biomed Pharmacother ・ PMID 39405908
inhalation
positive
animal study
Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.
2024 ・ Int J Med Sci ・ PMID 39310256
hydrogen-rich water
positive
human observational study
Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases.
2024 ・ Rev Cardiovasc Med ・ PMID 39077646
mixed routes
not assessed
review
Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing.
2024 ・ Natl Sci Rev ・ PMID 38213516
topical application
positive
animal study
Zn-Fe primary battery-enabled controlled hydrogen release in stomach for improving insulin resistance in obesity-associated type 2 diabetes.
2024 ・ Bioact Mater ・ PMID 38045569
mixed routes
positive
animal study
Clinical Use and Treatment Mechanism of Molecular Hydrogen in the Treatment of Various Kidney Diseases including Diabetic Kidney Disease.
2023 ・ Biomedicines ・ PMID 37893190
mixed routes
not assessed
review
Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study.
2023 ・ Front Nutr ・ PMID 37521410
hydrogen-rich water
mixed
human case report
Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment.
2023 ・ Pharmaceuticals (Basel) ・ PMID 37375765
not specified
not assessed
review
Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study.
2023 ・ Antioxidants (Basel) ・ PMID 37371975
hydrogen-rich water
positive
human randomized controlled trial
Therapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside.
2023 ・ Pharmaceuticals (Basel) ・ PMID 37111299
mixed routes
not assessed
review
Novel therapeutic approaches based on the pathological role of gut dysbiosis on the link between nonalcoholic fatty liver disease and insulin resistance.
2023 ・ Eur Rev Med Pharmacol Sci ・ PMID 36930488
hydrogen-rich water
not assessed
review
Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway.
2023 ・ J Neuroimmune Pharmacol ・ PMID 35895245
inhalation
positive
animal study
Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing.
2022 ・ Nat Commun ・ PMID 36167814
topical application
positive
animal study
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